AustralieFrV1, Main, Exploration, bibRecord, 004E36

Levels and Changes of HDL Cholesterol and Apolipoprotein A-I in Relation to Risk of Cardiovascular Events Among Statin-Treated Patients: A Meta-Analysis

Identifieur interne : 004E36 ( Main/Exploration ); précédent : 004E35; suivant : 004E37

Levels and Changes of HDL Cholesterol and Apolipoprotein A-I in Relation to Risk of Cardiovascular Events Among Statin-Treated Patients: A Meta-Analysis

Auteurs : S. Matthijs Boekholdt [Pays-Bas] ; Benoit J. Arsenault [Pays-Bas] ; G. Kees Hovingh [Pays-Bas] ; Samia Mora [États-Unis] ; Terje R. Pedersen [Norvège] ; John C. Larosa [États-Unis] ; K. M. A. Welch [États-Unis] ; Pierre Amarenco [France] ; David A. Demicco [États-Unis] ; Andrew M. Tonkin [Australie] ; David R. Sullivan [Australie] ; Adrienne Kirby [Australie] ; Helen M. Colhoun [Royaume-Uni] ; Graham A. Hitman [Royaume-Uni] ; D. John Betteridge [Royaume-Uni] ; Paul N. Durrington [Royaume-Uni] ; Michael B. Clearfield [États-Unis] ; John R. Downs [États-Unis] ; Antonio M. Jr Gotto [États-Unis] ; Paul M. Ridker [États-Unis] ; John J. P. Kastelein [Pays-Bas]

Source :

Circulation : (New York, N.Y.) [ 0009-7322 ] ; 2013.

RBID : Pascal:13-0343726

Descripteurs français

English descriptors

KwdEn :
- Angina, Unstable (epidemiology), Angina, Unstable (prevention & control), Antilipemic agent, Apolipoprotein A, Apolipoprotein A-I (blood), Cardiology, Cardiovascular Diseases (blood), Cardiovascular Diseases (drug therapy), Cardiovascular Diseases (epidemiology), Cardiovascular Diseases (prevention & control), Cardiovascular disease, Change, Cholesterol HDL, Cholesterol, HDL (blood), Cholesterol, LDL (blood), Circulatory system, Clinical Trials as Topic (statistics & numerical data), Evidence-based medicine, Follow-Up Studies, Heart Failure (epidemiology), Heart Failure (prevention & control), Human, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors (pharmacology), Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use), Hypercholesterolemia, Level, Lipids, Lipoprotein HDL, Metaanalysis, Myocardial Infarction (epidemiology), Myocardial Infarction (prevention & control), Patient, Peripheral Arterial Disease (epidemiology), Peripheral Arterial Disease (prevention & control), Phlebology, Proportional Hazards Models, Risk, Risk Factors, Risk Reduction Behavior, Risk factor, Statin derivative, Stroke (epidemiology), Stroke (prevention & control), Treatment, Treatment Outcome, Triglycerides (blood).
MESH :
- chemical , blood : Apolipoprotein A-I, Cholesterol, HDL, Cholesterol, LDL, Triglycerides.
- blood : Cardiovascular Diseases.
- drug therapy : Cardiovascular Diseases.
- epidemiology : Angina, Unstable, Cardiovascular Diseases, Heart Failure, Myocardial Infarction, Peripheral Arterial Disease, Stroke.
- chemical , pharmacology : Hydroxymethylglutaryl-CoA Reductase Inhibitors.
- prevention & control : Angina, Unstable, Cardiovascular Diseases, Heart Failure, Myocardial Infarction, Peripheral Arterial Disease, Stroke.
- statistics & numerical data : Clinical Trials as Topic.
- chemical , therapeutic use : Hydroxymethylglutaryl-CoA Reductase Inhibitors.
- Follow-Up Studies, Humans, Proportional Hazards Models, Risk Factors, Risk Reduction Behavior, Treatment Outcome.

Abstract

Background-It is unclear whether levels of high-density lipoprotein cholesterol (HDL-C) or apolipoprotein A-I (apoA-I) remain inversely associated with cardiovascular risk among patients who achieve very low levels of low-density lipoprotein cholesterol on statin therapy. It is also unknown whether a rise in HDL-C or apoA-I after initiation of statin therapy is associated with a reduced cardiovascular risk. Methods and Results-We performed a meta-analysis of 8 statin trials in which lipids and apolipoproteins were determined in all study participants at baseline and at 1-year follow-up. Individual patient data were obtained for 38 153 trial participants allocated to statin therapy, of whom 5387 suffered a major cardiovascular event. HDL-C levels were associated with a reduced risk of major cardiovascular events (adjusted hazard ratio [HR], 0.83; 95% confidence interval [CI], 0.81-0.86 per 1 standard deviation increment), as were apoA-I levels (HR, 0.79; 95% CI, 0.72-0.82). This association was also observed among patients achieving on-statin low-density lipoprotein cholesterol levels <50 mg/dL. An increase of HDL-C was not associated with reduced cardiovascular risk (HR, 0.98; 95% CI, 0.94-1.01 per 1 standard deviation increment), whereas a rise in apoA-1 was (HR, 0.93; 95% CI, 0.90-0.97).

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807966

Affiliations:

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Levels and Changes of HDL Cholesterol and Apolipoprotein A-I in Relation to Risk of Cardiovascular Events Among Statin-Treated Patients: A Meta-Analysis</title>
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<author><name sortKey="Pedersen, Terje R" sort="Pedersen, Terje R" uniqKey="Pedersen T" first="Terje R." last="Pedersen">Terje R. Pedersen</name>
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<author><name sortKey="Larosa, John C" sort="Larosa, John C" uniqKey="Larosa J" first="John C." last="Larosa">John C. Larosa</name>
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</inist:fA14>
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<wicri:noRegion>State University of New York Health Science Center</wicri:noRegion>
</affiliation>
</author>
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<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Rosalind Franklin University of Medicine and Science</s1>
<s2>North Chicago, IL</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Rosalind Franklin University of Medicine and Science</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Amarenco, Pierre" sort="Amarenco, Pierre" uniqKey="Amarenco P" first="Pierre" last="Amarenco">Pierre Amarenco</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neurology and Stroke Center, Bichat University Hospital</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
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<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Global Pharmaceuticals Pfizer</s1>
<s2>New York, NY</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Global Pharmaceuticals Pfizer</wicri:noRegion>
</affiliation>
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<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sullivan, David R" sort="Sullivan, David R" uniqKey="Sullivan D" first="David R." last="Sullivan">David R. Sullivan</name>
<affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Biochemistry and Lipid Clinic, Royal Prince Alfred Hospital, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Kirby, Adrienne" sort="Kirby, Adrienne" uniqKey="Kirby A" first="Adrienne" last="Kirby">Adrienne Kirby</name>
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<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Colhoun, Helen M" sort="Colhoun, Helen M" uniqKey="Colhoun H" first="Helen M." last="Colhoun">Helen M. Colhoun</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Medical Research Institute, University of Dundee</s1>
<s2>Dundee</s2>
<s3>GBR</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Dundee</wicri:noRegion>
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<author><name sortKey="Hitman, Graham A" sort="Hitman, Graham A" uniqKey="Hitman G" first="Graham A." last="Hitman">Graham A. Hitman</name>
<affiliation wicri:level="4"><inist:fA14 i1="13"><s1>Centre for Diabetes, Barts and The London School of Medicine and Dentistry, Queen Mary University of London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">Université de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Betteridge, D John" sort="Betteridge, D John" uniqKey="Betteridge D" first="D. John" last="Betteridge">D. John Betteridge</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Medicine, Royal Free and University College Medical School</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Durrington, Paul N" sort="Durrington, Paul N" uniqKey="Durrington P" first="Paul N." last="Durrington">Paul N. Durrington</name>
<affiliation wicri:level="4"><inist:fA14 i1="15"><s1>School of Biomedicine, University of Manchester</s1>
<s2>Manchester</s2>
<s3>GBR</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
<settlement type="city">Manchester</settlement>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
<author><name sortKey="Clearfield, Michael B" sort="Clearfield, Michael B" uniqKey="Clearfield M" first="Michael B." last="Clearfield">Michael B. Clearfield</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Touro University</s1>
<s2>Mare Island, CA</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Touro University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Downs, John R" sort="Downs, John R" uniqKey="Downs J" first="John R." last="Downs">John R. Downs</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Medicine, University of Texas Health Science Center, and VERDICT, South Texas Veterans Health Care System</s1>
<s2>San Antonio, TX</s2>
<s3>USA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>San Antonio, TX</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gotto, Antonio M Jr" sort="Gotto, Antonio M Jr" uniqKey="Gotto A" first="Antonio M. Jr" last="Gotto">Antonio M. Jr Gotto</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Weill Cornell Medical College</s1>
<s2>New York, NY</s2>
<s3>USA</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Weill Cornell Medical College</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Boston, MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J. P." last="Kastelein">John J. P. Kastelein</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Vascular Medicine, Academic Medical Center</s1>
<s2>Amsterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Circulation : (New York, N.Y.)</title>
<title level="j" type="abbreviated">Circulation : (N. Y. N.Y.)</title>
<idno type="ISSN">0009-7322</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Circulation : (New York, N.Y.)</title>
<title level="j" type="abbreviated">Circulation : (N. Y. N.Y.)</title>
<idno type="ISSN">0009-7322</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Angina, Unstable (epidemiology)</term>
<term>Angina, Unstable (prevention & control)</term>
<term>Antilipemic agent</term>
<term>Apolipoprotein A</term>
<term>Apolipoprotein A-I (blood)</term>
<term>Cardiology</term>
<term>Cardiovascular Diseases (blood)</term>
<term>Cardiovascular Diseases (drug therapy)</term>
<term>Cardiovascular Diseases (epidemiology)</term>
<term>Cardiovascular Diseases (prevention & control)</term>
<term>Cardiovascular disease</term>
<term>Change</term>
<term>Cholesterol HDL</term>
<term>Cholesterol, HDL (blood)</term>
<term>Cholesterol, LDL (blood)</term>
<term>Circulatory system</term>
<term>Clinical Trials as Topic (statistics & numerical data)</term>
<term>Evidence-based medicine</term>
<term>Follow-Up Studies</term>
<term>Heart Failure (epidemiology)</term>
<term>Heart Failure (prevention & control)</term>
<term>Human</term>
<term>Humans</term>
<term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (pharmacology)</term>
<term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)</term>
<term>Hypercholesterolemia</term>
<term>Level</term>
<term>Lipids</term>
<term>Lipoprotein HDL</term>
<term>Metaanalysis</term>
<term>Myocardial Infarction (epidemiology)</term>
<term>Myocardial Infarction (prevention & control)</term>
<term>Patient</term>
<term>Peripheral Arterial Disease (epidemiology)</term>
<term>Peripheral Arterial Disease (prevention & control)</term>
<term>Phlebology</term>
<term>Proportional Hazards Models</term>
<term>Risk</term>
<term>Risk Factors</term>
<term>Risk Reduction Behavior</term>
<term>Risk factor</term>
<term>Statin derivative</term>
<term>Stroke (epidemiology)</term>
<term>Stroke (prevention & control)</term>
<term>Treatment</term>
<term>Treatment Outcome</term>
<term>Triglycerides (blood)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Accident vasculaire cérébral ()</term>
<term>Accident vasculaire cérébral (épidémiologie)</term>
<term>Angor instable ()</term>
<term>Angor instable (épidémiologie)</term>
<term>Apolipoprotéine A-I (sang)</term>
<term>Cholestérol HDL (sang)</term>
<term>Cholestérol LDL (sang)</term>
<term>Comportement de réduction des risques</term>
<term>Défaillance cardiaque ()</term>
<term>Défaillance cardiaque (épidémiologie)</term>
<term>Essais cliniques comme sujet ()</term>
<term>Facteurs de risque</term>
<term>Humains</term>
<term>Infarctus du myocarde ()</term>
<term>Infarctus du myocarde (épidémiologie)</term>
<term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (pharmacologie)</term>
<term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (usage thérapeutique)</term>
<term>Maladie artérielle périphérique ()</term>
<term>Maladie artérielle périphérique (épidémiologie)</term>
<term>Maladies cardiovasculaires ()</term>
<term>Maladies cardiovasculaires (sang)</term>
<term>Maladies cardiovasculaires (traitement médicamenteux)</term>
<term>Maladies cardiovasculaires (épidémiologie)</term>
<term>Modèles de hasards proportionnels</term>
<term>Résultat thérapeutique</term>
<term>Triglycéride (sang)</term>
<term>Études de suivi</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Apolipoprotein A-I</term>
<term>Cholesterol, HDL</term>
<term>Cholesterol, LDL</term>
<term>Triglycerides</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Cardiovascular Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Cardiovascular Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Angina, Unstable</term>
<term>Cardiovascular Diseases</term>
<term>Heart Failure</term>
<term>Myocardial Infarction</term>
<term>Peripheral Arterial Disease</term>
<term>Stroke</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Angina, Unstable</term>
<term>Cardiovascular Diseases</term>
<term>Heart Failure</term>
<term>Myocardial Infarction</term>
<term>Peripheral Arterial Disease</term>
<term>Stroke</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Apolipoprotéine A-I</term>
<term>Cholestérol HDL</term>
<term>Cholestérol LDL</term>
<term>Maladies cardiovasculaires</term>
<term>Triglycéride</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Clinical Trials as Topic</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Maladies cardiovasculaires</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Accident vasculaire cérébral</term>
<term>Angor instable</term>
<term>Défaillance cardiaque</term>
<term>Infarctus du myocarde</term>
<term>Maladie artérielle périphérique</term>
<term>Maladies cardiovasculaires</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Follow-Up Studies</term>
<term>Humans</term>
<term>Proportional Hazards Models</term>
<term>Risk Factors</term>
<term>Risk Reduction Behavior</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Accident vasculaire cérébral</term>
<term>Angor instable</term>
<term>Comportement de réduction des risques</term>
<term>Défaillance cardiaque</term>
<term>Essais cliniques comme sujet</term>
<term>Facteurs de risque</term>
<term>Humains</term>
<term>Hypercholestérolémie</term>
<term>Infarctus du myocarde</term>
<term>Maladie artérielle périphérique</term>
<term>Maladies cardiovasculaires</term>
<term>Modèles de hasards proportionnels</term>
<term>Niveau</term>
<term>Changement</term>
<term>Lipoprotéine HDL</term>
<term>Cholestérol HDL</term>
<term>Apolipoprotéine A</term>
<term>Facteur risque</term>
<term>Risque</term>
<term>Pathologie de l'appareil circulatoire</term>
<term>Dérivé de la statine</term>
<term>Résultat thérapeutique</term>
<term>Traitement</term>
<term>Homme</term>
<term>Malade</term>
<term>Métaanalyse</term>
<term>Médecine factuelle</term>
<term>Appareil circulatoire</term>
<term>Cardiologie</term>
<term>Phlébologie</term>
<term>Lipide</term>
<term>Hypolipémiant</term>
<term>Maladie cardiovasculaire</term>
<term>Études de suivi</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background-It is unclear whether levels of high-density lipoprotein cholesterol (HDL-C) or apolipoprotein A-I (apoA-I) remain inversely associated with cardiovascular risk among patients who achieve very low levels of low-density lipoprotein cholesterol on statin therapy. It is also unknown whether a rise in HDL-C or apoA-I after initiation of statin therapy is associated with a reduced cardiovascular risk. Methods and Results-We performed a meta-analysis of 8 statin trials in which lipids and apolipoproteins were determined in all study participants at baseline and at 1-year follow-up. Individual patient data were obtained for 38 153 trial participants allocated to statin therapy, of whom 5387 suffered a major cardiovascular event. HDL-C levels were associated with a reduced risk of major cardiovascular events (adjusted hazard ratio [HR], 0.83; 95% confidence interval [CI], 0.81-0.86 per 1 standard deviation increment), as were apoA-I levels (HR, 0.79; 95% CI, 0.72-0.82). This association was also observed among patients achieving on-statin low-density lipoprotein cholesterol levels <50 mg/dL. An increase of HDL-C was not associated with reduced cardiovascular risk (HR, 0.98; 95% CI, 0.94-1.01 per 1 standard deviation increment), whereas a rise in apoA-1 was (HR, 0.93; 95% CI, 0.90-0.97).</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Norvège</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Grand Manchester</li>
<li>Hollande-Septentrionale</li>
<li>Nouvelle-Galles du Sud</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Amsterdam</li>
<li>Londres</li>
<li>Manchester</li>
<li>Melbourne</li>
<li>Paris</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université de Londres</li>
<li>Université de Manchester</li>
<li>Université de Sydney</li>
</orgName>
</list>
<tree><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Boekholdt, S Matthijs" sort="Boekholdt, S Matthijs" uniqKey="Boekholdt S" first="S. Matthijs" last="Boekholdt">S. Matthijs Boekholdt</name>
</region>
<name sortKey="Arsenault, Benoit J" sort="Arsenault, Benoit J" uniqKey="Arsenault B" first="Benoit J." last="Arsenault">Benoit J. Arsenault</name>
<name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J. P." last="Kastelein">John J. P. Kastelein</name>
<name sortKey="Kees Hovingh, G" sort="Kees Hovingh, G" uniqKey="Kees Hovingh G" first="G." last="Kees Hovingh">G. Kees Hovingh</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Mora, Samia" sort="Mora, Samia" uniqKey="Mora S" first="Samia" last="Mora">Samia Mora</name>
</noRegion>
<name sortKey="Clearfield, Michael B" sort="Clearfield, Michael B" uniqKey="Clearfield M" first="Michael B." last="Clearfield">Michael B. Clearfield</name>
<name sortKey="Demicco, David A" sort="Demicco, David A" uniqKey="Demicco D" first="David A." last="Demicco">David A. Demicco</name>
<name sortKey="Downs, John R" sort="Downs, John R" uniqKey="Downs J" first="John R." last="Downs">John R. Downs</name>
<name sortKey="Gotto, Antonio M Jr" sort="Gotto, Antonio M Jr" uniqKey="Gotto A" first="Antonio M. Jr" last="Gotto">Antonio M. Jr Gotto</name>
<name sortKey="Larosa, John C" sort="Larosa, John C" uniqKey="Larosa J" first="John C." last="Larosa">John C. Larosa</name>
<name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name>
<name sortKey="Welch, K M A" sort="Welch, K M A" uniqKey="Welch K" first="K. M. A." last="Welch">K. M. A. Welch</name>
</country>
<country name="Norvège"><noRegion><name sortKey="Pedersen, Terje R" sort="Pedersen, Terje R" uniqKey="Pedersen T" first="Terje R." last="Pedersen">Terje R. Pedersen</name>
</noRegion>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Amarenco, Pierre" sort="Amarenco, Pierre" uniqKey="Amarenco P" first="Pierre" last="Amarenco">Pierre Amarenco</name>
</region>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Tonkin, Andrew M" sort="Tonkin, Andrew M" uniqKey="Tonkin A" first="Andrew M." last="Tonkin">Andrew M. Tonkin</name>
</region>
<name sortKey="Kirby, Adrienne" sort="Kirby, Adrienne" uniqKey="Kirby A" first="Adrienne" last="Kirby">Adrienne Kirby</name>
<name sortKey="Sullivan, David R" sort="Sullivan, David R" uniqKey="Sullivan D" first="David R." last="Sullivan">David R. Sullivan</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Colhoun, Helen M" sort="Colhoun, Helen M" uniqKey="Colhoun H" first="Helen M." last="Colhoun">Helen M. Colhoun</name>
</noRegion>
<name sortKey="Betteridge, D John" sort="Betteridge, D John" uniqKey="Betteridge D" first="D. John" last="Betteridge">D. John Betteridge</name>
<name sortKey="Durrington, Paul N" sort="Durrington, Paul N" uniqKey="Durrington P" first="Paul N." last="Durrington">Paul N. Durrington</name>
<name sortKey="Hitman, Graham A" sort="Hitman, Graham A" uniqKey="Hitman G" first="Graham A." last="Hitman">Graham A. Hitman</name>
</country>
</tree>
</affiliations>
</record>

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   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:13-0343726
   |texte=   Levels and Changes of HDL Cholesterol and Apolipoprotein A-I in Relation to Risk of Cardiovascular Events Among Statin-Treated Patients: A Meta-Analysis
}}

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Serveur d'exploration sur les relations entre la France et l'Australie

Levels and Changes of HDL Cholesterol and Apolipoprotein A-I in Relation to Risk of Cardiovascular Events Among Statin-Treated Patients: A Meta-Analysis

Levels and Changes of HDL Cholesterol and Apolipoprotein A-I in Relation to Risk of Cardiovascular Events Among Statin-Treated Patients: A Meta-Analysis

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	Serveur d'exploration sur les relations entre la France et l'Australie
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